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A full and diverse evening of Esprit

Are you fishing behind the net? Have you hung your coat in the direction of the wind?

Nine Proverbs, a dramatic, highly coloured orchestral piece she completed in 2002. Esprit Orchestra gave it a whirl on Wednesday during a concert that also included hefty works by Maki Ishii, Valentin Silvestrov and Unsuk Chin.

Those two synonyms for futile or tardy action are pictured literally in a painting by Pieter Brueghel the Younger. Montreal composer Ana Sokolovic saw the painting, which also depicts seven more proverbs, at the Art Gallery of Ontario and went looking for sounds to match the work's barbed folk wisdom and robust visual style.

The crowded sociability of Brueghel's painting invaded each of Sokolovic's sonic pictures, which rippled with an energy that turned manic in a couple of wild yelping episodes for two E flat clarinets. This was the most amusingly deranged music I've ever heard for an instrument often typecast for its shrill, excitable sound. She also pitched a double bass solo (played by Tom Hazlitt) at the uppermost extreme of its register, and engineered a joint effort by grumbling basses and trombones that sounded like a small plane idling. Several of her wind combinations were so well and unusually blended that I couldn't quite catch the recipe on one hearing.

Nine Proverbs began with a bright, bird like clamour, spiked by mock heroic flourishes from the trumpets this for "falling between two stools into ashes," or being unable to make up one's mind. A solitary state of confusion, depicted with many players, naturally became Men Canada Goose Borden Bomber Red Australia Sale an external projection of the mind's internal bickering.

My one complaint about this piece was that its continuous form made it difficult to connect music with proverb. The orchestra's moody accompaniments often had a geologic weight, as masses of sound shifted against each other almost arrhythmically. The piano, played by Ivan Sokolov, cast fragrant sprays over the broad orchestral actions, emerging more prominently to deliver a pop like tune with an accompaniment that wouldn't have been out of place in a song by Alicia Keys. The orchestra, meanwhile, doggedly repeated to a short, unstable tunelet in a different key. Much of the piece felt like a struggle between forces of fluctuating intensity: a chorale like section for winds, for instance, stood calmly against a series of shrieking attacks from the violins. This music suffered perhaps by coming at the end of a packed program, and also by rather prosaic direction from conductor Alex Pauk, who often seemed content to merely beat time through sustained sections that needed more shape, and more feeling. He and the orchestra had better innings in the other pieces, especially.

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Bear, 23, was reported missing Sept. 5, 2013, although police have said the exact time and date of her disappearance is not known.

REGINA A Regina man has pleaded guilty to killing a young mother whose body was dumped in an industrial garbage bin and of another woman whose remains have never been found.

The Crown and defence made a joint submission that Eichler serve 20 years of his automatic life sentence before being eligible for parole.

Goforth was last seen Sept. 24, 2013.

"That led to a search of Mr. Eichler's home where we found photographs of Richele Bear. It was very obvious that she was not participating in what was happening in these photographs, and she had a mark around her neck, which made it appear that she was certainly dead," he said.

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"There will be aspects of Kelly and Richele's lifestyles that will be exposed to the public," the release said. "It is the responsibility of all of us as citizens to understand the realities and the vulnerabilities of our indigenous women are due to the immense poverty that is often faced by our indigenous people in the cities.

Court heard her body was found the next day, wrapped in garbage bags, placed in a hockey bag and thrown in a Dumpster. She was 21 years old and had a young son.

Gray said she still doesn't feel closure because Bear's body cannot be properly buried.

The File Hills Qu'Appelle Tribal Council and the Regina Treaty Status Indian Services office said the women were valued daughters, sisters, aunts, nieces, granddaughters, cousins and friends.

Clayton Eichler's trial was to begin Monday on charges of first degree murder in the deaths of Kelly Goforth and Richele Bear. But there was a surprise guilty plea to second degree murder.

"I believe 20 years is not enough of a sentence for the girls' death sentence. I feel he should get two life sentences," said Gray, as she wiped her eyes with a tissue.

Accused in deaths of 2 women pleads guilty at start of trial

"The cause of death of Kelly Goforth was ligature strangulation and, when you look at both of these together, it became clear what happened to Richele Bear."

Burge said DNA found on Goforth's hand and on a necktie around her neck belonged to Eichler.

Bear's aunt, Angela Gray, said the guilty plea was a long time coming, but she's satisfied with it.

Victim impact statements were scheduled to be heard Tuesday before sentencing.

"There was a path to first degree. It wasn't a dead certain path, but there was a path that met the test for prosecution. There were risks and we felt this was a compromise we could live with and that's why we took the plea to second degree," Burge said outside Court of Queen's Bench in Regina.

"I've reviewed all the transcripts, I've reviewed all the evidence and I thought that on one count he would be convicted of second degree murder. On the other count, I thought there was a strong possibility . so I made a call to do that," said Bodnar.

He would not say if Eichler has ever expressed remorse or given a motive for the killings.

Defence lawyer Morris Bodnar said he was ready for the trial to start when Eichler, 35, changed his plea. Bodnar Cheap Men Canada Goose Langford Parka Black Australia said it was the advice he had given Eichler.

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Nature Canada, another group involved in the study, called for more than $80 million for research and conservation as well as the creation of national wildlife areas and marine conservation areas. The group also wants Ottawa to stop the province of Saskatchewan's plan to sell or lease Women Canada Goose Victoria Parka Berry Australia Sale community pastures.

Only two groups of birds are increasing, says the report. That's because waterfowl such as ducks and geese and raptors such as peregrine falcons already benefit from conservation actions.

The three national governments are expected to sign a letter of intent Wednesday to work more closely together to protect birds on a continental scale.

"The solutions require international collaboration," said Charles Francis of the Canadian Wildlife Service, who co ordinated the bird report.

"This is a continuation of trends we've known from national reports in the not too distant past," said Steven Price of Bird Studies Canada, one of more than a dozen non profit groups also involved in the study.

A third of North American birds at risk

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Of the 1,154 species of birds that fill the forests, marshes, coastlines and grasslands from the Yucatan peninsula to Baffin Island, 432 of them are considered at high risk of vanishing from the skies forever, according to the North American Bird Conservation Initiative.

Worst off are seabirds. The report found seabird populations have declined by nearly three quarters since the 1950s and that 57 per cent of those species are on the road to extinction without conservation action.

Some groups have called for half of Canada's boreal forest to come under some kind of protection. Quebec and Ontario have agreed to try to meet that goal.

The culprits behind the losses are familiar. Habitat chewed up by homes, farms or industry is a major contributor. So is pollution. Climate change alters once familiar homes quicker than birds can adjust.

Fully one third of all North American bird species need quick help to stop them from disappearing, says the first continent wide bird study conducted jointly by Canada, the United States and Mexico.

A 2014 study by the Audubon Society found climate change could cost 126 species more than half their current range by 2050. A McGill University study in 2015 concluded more than 70 per cent of global forests are within a kilometre of a road, field, town or other human disturbance easily close enough to degrade forest habitat.

Tropical and subtropical species are almost as bad off. And the report adds that between one quarter and one third of species along coasts, on the prairies or in drylands are going the way of the dodo.

Even in the boreal forest, the vast swath of green along the northern ends of the provinces, about 20 per cent of all species are in danger of dying out.

"We spent money and changed policies and these birds have recovered," Stevens said.

The results have been echoed in previous studies.

"It gives focus to the staff within Environment Canada to spend greater effort on continuing to work internationally."

Francis said the letter commits the countries to work together to protect bird populations shared by all three while allowing local people to earn a living on the landscape. The document won't be immediately accompanied by any funding or specific policy goals but will set the stage, Francis said.

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A huge flock of Canada geese greeted us at the access when we revisited New Bedford Reservoir, and many small groups of wood ducks fled before us as we paddled up the channel. In spring, nesting songbirds fill the surrounding area. In July, swamp azalea and swamp rose bloom in profusion along the wooded shore, where green and great blue herons stalk fish and amphibian prey and mute swans eat their fill of abundant aquatic vegetation. In mid September, early migrating blue winged teal join the resident waterfowl. A highly varied shoreline and many marshy coves provide a haven for all sorts of waterfowl and wetland plants. Don't expect easy paddling, though. Expect to see: mute swan, Canada goose, wood duck, mallard, great blue heron, green heron.

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A huge flock of Canada geese greeted us at the access when we revisited New Bedford Reservoir, and many small groups of wood ducks fled before us as we paddled up the channel. In spring, nesting songbirds fill the surrounding area. In July, swamp azalea and swamp rose bloom in profusion along the wooded shore, where green and great blue herons stalk fish and amphibian prey and mute swans eat their fill of abundant aquatic vegetation. In mid September, early migrating blue winged teal join the resident waterfowl. A highly Cheap Women Canada Goose Whistler Parka Black Australia varied shoreline and many marshy coves provide a haven for all sorts of waterfowl and wetland plants. Don't expect easy paddling, though. Expect to see: mute swan, Canada goose, wood duck, mallard, great blue heron, green heron.

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College Park second baseman Billy Hamant can't handle a bad hop on a grounder by Acalanes' Matt Burns, during the ninth inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Speer also overran the ball, allowing two runs to score, and Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

Acalanes center fielder Will Rembac (3) tries to dissuade a Canada goose from camping out on the field of play during the ninth inning of a high school baseball game against College Park, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

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Acalanes' Grant Young (22) and teammate Kevin McConnell celebrate their extra inning win over College Park in a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

College Park pitcher Ian Maciver (6) runs into foul ground to catch a foul popup by Acalanes' Nick Taylor (7) during the sixth inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Speer chases down a leadoff triple by Acalanes' Daniel Kim during the seventh inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

Acalanes shortstop Matt Burns tell his teammates to hold the relay as College Park's Josh Nelson (21) slides safely into second base with a double during a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

College Park starting pitcher Kellen Kozlowski delivers against Acalanes during the third inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Kellen Kozlowski took a no decision as Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

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Acalanes relief pitcher Grant Young (22) delivers against College Park during the fifth inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

Acalanes takes on College Park during the second inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

Acalanes third baseman Tyler Ewing scoops up a College Park grounder during the fourth inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

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College Park shortstop Christian Encarnacion Strand, left, puts the tag on Acalanes' Will Rembac (3) as he attempts to steal second base during the fifth inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

Acalanes center fielder Will Rembac (3) tries to dissuade a Canada goose from camping out on the field of play during the ninth inning of a high school baseball game against College Park, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

College Park shortstop Christian Encarnacion Strand can't get a glove on a bases loaded grounder up the middle by Acalanes that struck the umpire, in the ninth inning of a high school baseball game tied 2 2, Wednesday, April 6, 2016, in Pleasant Hill, Calif. A run scored on the dead ball, and Acalanes tacked on two more runs to win, 5 2. (D. Ross Cameron/Bay Area News Group)

College Park center fielder Josh Nelson makes a sliding catch of a sinking liner by Acalanes' Jake Berry to end the top of the third inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

College Park second baseman Billy Hamant dives in vain for a line drive up the middle by Acalanes, during the eighth inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

The Acalanes High School Dons took nine innings to do it, but they beat the host College Park Falcons on the diamond, Wednesday, April 6, 2016, in Pleasant Hill, Calif. With the score tied 2 2 in the top of the ninth inning, a bases loaded grounder struck the second base umpire a dead ball that allowed the go ahead run to score for Acalanes. Two batters later, Will Rembac bounced a grounder past Falcons second baseman Billy Hamant and the Dons had a three run cushion that they made stand up for the win. (Photos by D. Ross Cameron/Bay Area News Group)

College Park hurler Ian Maciver (6) turns and throws out Acalanes' Cole Christensen on a comebacker during the seventh inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

College Park starting pitcher Kellen Kozlowski delivers against Acalanes during the third inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Kozlowski took a no decision as Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

Acalanes' Daniel Kim (4) exults as he slides safely into third base with a triple, while College Park third baseman Braeden Gowdy takes the late relay to start off the seventh inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Kim later scored on a sacrifice fly to force extra innings, and Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

Acalanes' Daniel Kim (4) scores on Tyler Ewing's sacrifice fly to right field as College Park catcher Jack Downing takes the late relay, during the seventh inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. The play tied the score at 2 2, and Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

Acalanes' Daniel Kim (4) slides safely into third base with a triple as College Park third baseman Braeden Gowdy takes the late relay to start off the seventh inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Kim later scored on a sacrifice fly to force extra innings, and Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

Acalanes starting pitcher Josh Candau (16) hands the ball over to coach Justin Santich Hughes during the fourth inning of a high school baseball game against College Park, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Candau allowed two runs and took a no decision as his team won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

Acalanes' Will Rembac (3) slides safely back into first base ahead of a pickoff throw to College Park first baseman Jackson Driver (3) during the seventh inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

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A bloop double Canada Goose Discount Liuigno Parka Australia off the bat of College Park's Josh Nelson falls behind Acalanes first baseman Cole Christensen (13) during the fifth inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

College Park's Ian Maciver delivers against Acalanes during the ninth inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Maciver took the loss as Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

Acalanes shortstop Matt Burns backpedals to make a catch of a popup by College Park's Ian Maciver to quell a threat in the fourth inning of a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

Acalanes players celebrate their extra innings win over College Park in a high school baseball game, Wednesday, April 6, 2016, in Pleasant Hill, Calif. Acalanes won in nine innings, 5 2. (D. Ross Cameron/Bay Area News Group)

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Each holiday season, you can bet you'll be hearing the song "It's the Most Wonderful Time of the Year" by Andy Williams. And just as Andy is a holiday favorite, so is Starbucks Christmas Blend coffee for me in fact, some coffee hounds can hardly wait to get a cupful of that seasonal brew of choice.

Either way, I think it's an interesting sales tactic: Offering a special version of your product for a limited time, and then tweak the formula each year. Consumers who love a particular item will stockpile the product out of fear it won't be exactly the same next year. On the other hand, you may lose customers who prefer a consistent, high quality product.

Avid fans of Starbucks' Buy Men Canada Goose Langford Parka Grey Australia Christmas Blend (also called Holiday Blend) from previous years have even logged onto eBay in hopes of buying their favorite coffee blend online. Interestingly, many Starbucks fans believe that the company modifies its Christmas Blend just a little each year. Personally, I can't tell the difference in the taste from one year to the next. Since coffee is a crop, I wouldn't be surprised if the flavor is affected by weather, soil conditions, or other variables beyond Starbucks control.

Is your company offering a special holiday version of a product or service to lure business? What are you doing to drum up holiday sales?

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A recent international Ipsos Reid survey conducted on behalf of Canada Goose, found that more than two thirds of people feel that a life without adventure big or small is no life at all, yet just over half actually put that aspiration into action: 43 per cent admitted they rarely or never go on an adventure, and less than ten per cent describe themselves as courageous. And despite their belief that it can be as simple as experiencing something new or moving beyond their comfort zone, not having enough time or money were the top two barriers (34 per cent and 58 per cent respectively) preventing respondents from embracing life. One in ten also said fear and weather were responsible for holding them back.

TORONTO, Nov. 10, 2015 /PRNewswire/ Canada Goose, one of the world's leading makers of luxury apparel, today released OUT THERE, a short film directed by Academy Award winning filmmaker and director, Paul Haggis. The focus of its first ever global brand campaign, OUT THERE chronicles the unbelievable Cheap Women Canada Goose Expedition Parka Brown Australia true stories and triumphs of explorers and everyday adventurers who have survived harrowing situations and accomplished incredible feats.

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"For us, true luxury means access to new experiences, big ideas, and discovering the unexpected," said Dani Reiss, President and CEO, Canada Goose. "Built over the last 58 years, our story is one of wildness, independence and courage. OUT THERE tells the incredible true stories our story that inspire people to explore and embrace their innate desire for adventure."

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Grouse wings wanted

Feather characteristics allow biologists to differentiate male grouse from females, and juveniles from adults, which helps them monitor production, reconcile bird counts and get a better understanding of the harvest composition.

Another change in the small game and furbearer regulations is that trappers are no longer required to register in order to use cable devices. The primary purpose for the registration system the past two seasons was to formulate a mailing list of cable device users in North Dakota, and Game and Fish has accomplished that with more than 1,100 registered cable device users.

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For instance, if the early season harvest is four lions at the time the season closes, hunters could take four more lions if the early season is reopened later on. The early season can reopen if the late season harvest limit is reached prior to March 25, 2017.

This time of year it seems like every week there is new information coming out about hunting seasons or regulations or license applications. Here's a recap of some recent topics from North Dakota Game and Fish Department news:

A recap for upcoming hunting seasons and regulations

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Small game, furbearer regulations

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North Dakota's 2016 small game and furbearer regulations are set and most season structures are similar to last year.

The Game and Fish Department is once again asking grouse hunters for help with future bird management, by collecting wing and other feathers from harvested birds and returning them in special envelopes.

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The late season limit stays the same as last year at seven, but a new provision this year has the late season closing if hunters take three female mountain lions.

One notable change involves the mountain lion season harvest limit, which is reduced from 21 last year to 15 this year. The early season limit is reduced from 14 to eight. However, if the early season limit is not reached before that season ends on Nov. 20, it could reopen later on, after the late season closes.

Also pertaining to furbearers, night vision, electronically enhanced light gathering optics, and thermal imaging equipment is now legal during the portion of the red fox, gray fox and coyote seasons that is open to night hunting (Nov. 21 March 15). Spotlights or any other artificial lights are still prohibited.

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It is great for the country side though if you and if you are a chill out type of person. For city dwellers Canada Goose offers more slimmer, non fur hood options that are just as popular as the Banff Parka.

Is the Banff Parka a good winter jacket?The Banff Parka is a great jacket. It may be too warm and restrictive for city dwellers, but that depends on which city we are talking about. It is neither completely made for outdoors. I would say this is a jacket for lay back people that wont move around so much around the city and want to look very formal, with a scarf.

A great outdoor parka would be either the Constable (which is also an urban style) or the Expedition Parka.

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A better choice for the city would be the Burnett Parka.

This are all cultural based tips that you will find no where else to date colombian women. From how to dance with them, drinks and even what matters most when meeting the family.

Warmth Perfect for outdoors, But too hot for indoorsFor starters, this is an extreme weather parka right for temperatures down to 25, so you buy it knowing it will be only used in really cold locations. The thing is that in a city you are almost never completely outdoors. You are in the car, the bus, the office, inside the house or in the market. The extra activity plus the warmth in all of those places make the Banff an extra warm jacket for Men Canada Goose Heli Arctic Parka Black Australia the city.

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Check out Andrew Garfield, from the "Amazing Spiderman" movie wearing a Banff Parka on the set of the second part of the movie. This is New york, February 2013.

The parka is also a bit heavy. Something completely normal taking into account this is an extreme weather jacket filled with white duck down.

Tight and slightly heavyThis is a slim fit parka, which means things are going to get tight in there. A little restrictive if you were expecting to flap your arms around like a bird, but this can be solved by getting one size larger than your usual parka size, which you should strongly consider.

On when you step outside, off when you step inside.

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Style Buttons are a burden hereCanada Goose is very clear about it, this is a stylish jacket for extreme cold weather. You wear the Banff to look formal instead of something like the Mantra where the looks dont matter. The issue comes with the buttons.

This is something you dont think about in the store, you buy it, and once you are out there you might be too late to return it.

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Unbuttoning every time you move through different environments is annoying. And that goes for the pockets as well. Some have suggested leaving the parka unbuttoned, but then the organized look it you liked it for goes away.

The Banff Parka comes with buttons along the storm flap and on the side pockets. They look great. In fact, they are what make the Banff such a stylish parka. But when it comes to practicality buttons can be very annoying. You got a warm parka which probably is going on and off several times a day.

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UPDATE (June 27, 2014): I receive more correspondence on this story than any other! You can find a much more detailed post about artemisinin here. The post is from 2012.

In 2003, Jay Keasling and his team at UC Berkeley announced initial success in an endeavor that has since become "the" poster child success story of synthetic biology. They had successfully implanted genes into E. coli that are part of a metabolic pathway that produces a precursor to the antimalarial drug artemisinin. They would go on to engineer the entire pathway into yeast with multimillion dollar financial support from the Bill and Melinda Gates Foundation. It is much cheaper to use yeast to produce the precursor and then convert it to artemisinin than it is to synthesize artemisinin outside of living cells.

A Synthetic Biology Success Story

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In nature, artemisinin is produced by the plant Artemisia annua (see picture). The global supply of artemisinin comes almost exclusively from farmers that cultivate the plant. However, the global supply of artemisinin is highly volatile because of the uncertainty associated with crop success. Keasling and his team wanted to provide a cheap and reliable alternative to agricultural production. This required engineering an entire non native metabolic pathway into yeast cells. "Metabolic engineering" is becoming a real buzz word in synthetic biology. Canada Goose Cheap Chilliwack Bomber Australia Craig Venter, for instance, is working to develop bioreactors in which algae cells convert carbon dioxide from the atmosphere into fuel. Whether in the areas of medicine, energy, environment, or something else, the applications of this technology are of immense importance. The attention garnered by Keasling's achievements even secured him a spot as Discover Magazine's scientist of the year in 2006, the year he reported that the entire pathway had been constructed in yeast.

According to the World Health Organization (WHO), there were 247 million cases of malaria in 2008 alone. The same year almost one million sufferers perished from the illness. The malaria parasite is spread by mosquitos, and those residing within tropical climates are particularly at risk (the red areas in the map). Though the disease can be treated with antimalarial drugs, there is limited access to medical care in the poorest of the affected regions. On top of that, many populations of the parasite have evolved resistance to the popular drugs chloroquine and sulfacoxine pyrimethamine. Artemisinin has not been met with widespread parasite resistance, and WHO warns that if such resistance developed "the public health consequences could be dire, as no alternative antimalarial medicines will be available in the near future." Clearly artemisinin is a key player in our arsenal against this disease.

At this point it isn't clear exactly what benefits we will reap from metabolic engineering technologies in the near future. Noorden (2010) reports that the price of artemisinin coming out of traditional agriculture has fallen so much that producing it in a bioreactor would not lower the cost as initially anticipated. However all is not lost as the new technology can pick up the slack during bad crop years. It is also worth noting that this advance is, quite possibly, only the tip of the iceberg when it comes to metabolic engineering. As our knowledge of biology and techniques for engineering it advance, I believe we might see considerable changes in industries like drug manufacturing, food production, and energy generation. Cells really are little factories, and they are amazingly efficient at what they do.